Lipoid Kosmetik Launches a New Active Ingredient

Lipoid Group, with a total of 4 factories in Germany and Switzerland, is one of the world's largest producers of natural raw materials for the Food, Pharmaceutical and Cosmetics industries. High-quality plant-based actives and extracts (Lipoid Kosmetik AG, Switzerland) and Food, Cosmetics and Pharma grade natural lectins/phospholipids (Lipoid GmbH, Germany) form part of a sophisticated product portfolio. A pioneer in the production of Plant Extract, Active and Liposomal products, Lipoid Kosmetik has become one of the indispensable suppliers to the global cosmetics industry over the past 45 years. This long-standing expertise, combined with the exceptional quality of its portfolio, enables its customers to develop innovative, functional and natural cosmetic products that meet the highest standards.

A Newly Awarded Active: Phytocodine®

A person's perceived age is determined by physical characteristics of the face and neck. These characteristics largely reflect the integrity of the extracellular matrix, which provides skin with homogeneity and elasticity. Matrikines are dermal messenger peptides that tell skin cells to reorganize and improve the extracellular matrix. Until now, synthetic matrikines have generally been used in cosmetics. Lipoid Kosmetik, however, investigated natural matrikine-like peptides from cedar nuts and developed this brand new anti-aging active: PhytoCodine®. PhytoCodine® mimics the activity of matrikines naturally found in our skin. By activating the formation of extracellular matrix components, PhytoCodine® optimizes skin structure and prevents age-related characteristics of mature skin such as loss of elasticity, wrinkles and sagging. PhytoCodine® is the world's first plant-based natural matrikine-like peptide concentrate. It reprograms fibroblasts to create the characteristic extracellular matrix components of youthful-looking skin, thus PhytoCodine® directly contributes to a person's perceived age.

Magnificent Combination Active Content: Matrikine-Like Peptide

PhytoCodine® contains natural matrikine-like peptides from cedar nuts that improve the extracellular matrix (ECM formation). Matrikines are naturally found in our skin and activate intracellular signaling pathways that lead to the accumulation of the extracellular matrix.

Functional Content: For Bioactive Peptides

PhytoCodine® increases the penetration of matrikine-like peptides. Peptides are small molecules that must penetrate skin layers to reach dermal fibroblasts (sites of action). PhytoCodine® contains a liposomal delivery system for hydrophilic active components that enhance penetration. In vivo studies using Raman spectroscopy show that penetration of model actives increases by 50% following topical application.

Functional Content: Natural Protectors

PhytoCodine® protects the bioactivity of matrikine-like peptides. Matrikine-like messenger peptides are susceptible to proteolytic degradation. Protease activity in the extracellular space rapidly breaks down peptides and destroys their biological activity. Similarly, collagen and elastin are also susceptible to proteolytic degradation. PhytoCodine® contains highly potent protease inhibitors derived from Siberian ginseng (Eleutherococcus senticosus). Figure 4: PhytoCodine® consists of natural messenger peptides that mimic the action of matrikines naturally produced in our skin. Thus PhytoCodine® activates the formation of extracellular matrix proteins and improves age-related characteristics of skin.  

Beren Elmasdiken

Chemical Engineer Head of Sales and Marketing Oktrade Dış Tic. Ltd. Şti.