To this day, highly viscous liquids such as creams, lotions, shampoo, toothpaste or nail polish are processed almost exclusively with the help of spoons and other similar tools in the laboratory and for analytical purposes.
These requirements cause tremendous delays to analysis and mixing procedures during the development process.
For example, several material-intensive steps are consistently required for exact determination of the liquid volume: in an initial time-consuming step, the highly viscous liquids are transferred between different vessels, followed by weighing and calculating the volume by consulting the liquid’s specific density.
In order to process aqueous liquids precisely, modern laboratories also use pipettes with different functional principles, each equipped with the respective consumable tips. For viscous liquids in particular, those pipettes that function according to the direct displacement principle, similar to that of a syringe, have prevailed.
However, increasing viscosity leads to growing flow resistance inside the tip. The consequence: either the hand strength of the operator, the material comprising the operational controls, or the motors of electronic pipettes will reach their limit.
Additionally, the processing speed will decrease with increasing viscosity, particularly if precision is of the essence. Up to now, the limit of the dynamic viscosity – which is dependent on the capacity of the pipetting system or the operator, respectively – consistently ranged between approximately 200 and 300 mPa*s (10 mL tip volume).
This is roughly equivalent to the viscosity of 86% glycerol at 20°C.
A new invention by the company Eppendorf, which has been developing Liquid Handling Instruments for the past 57 years, is about to dissolve this limit.
The new ViscoTip® for the associated Multipette instrument is purportedly capable of processing tough liquids such as creams with viscosities of up to 14,000 mPa*s precisely and quickly. It will be introduced to the public for the first time in April 2018 at the InCosmetics.
Dr. Samira Schroeder
Global Marketing Manager
Manuel Liquid Handling
Eppendorf AG
