Lipoid Kosmetik is a leading manufacturer of natural raw materials for the cosmetic and personal care industry. High-quality botanical actives and extracts (Lipoid Kosmetik AG, Switzerland) as well as pharma grade natural lecithins and phospholipids (Lipoid GmbH, Germany) are part of our sophisticated port- folio. As a pioneer in these fields, Lipoid Kosmetik has gained an outstanding reputation in the global cosmetic industry over the last 45 years. This longstanding expertise, in combination with the exceptional quality of our portfolio, enables our customers to develop innovative, functional and natural cosmetic products meeting the highest standards.
The Newest Product of Lipoid Kosmetik: Phytocodine®
A person’s perceived age is determined by physical traits on face and neck. These traits mostly reflect the integrity of the extracellular matrix, which provides structure, homogeneity and elasticity to skin. Matrikines are dermal messenger peptides that instruct skin cells to reorganize and build-up the extracellular matrix. So far, synthetic matrikines have been used in cosmetics. Now, Lipoid Kosmetik investigated and isolated – for the first time – natural matrikine-like peptides from cedar nuts, and presents them in a novel anti-aging concentrate: PhytoCodine®.
We show that PhytoCodine® mimics the activity of matrikines that naturally occur in our skin. PhytoCodine® activates the formation of extracellular matrix components, optimizes skin structure, and improves age-related properties of mature skin, such as elasticity, density, wrinkles and sagging. Taken together, PhytoCodine® is the world’s first concentrate of plant-derived, natural matrikine-like peptides. It reprograms fibroblasts to build-up extracellular matrix components characteristic of younger looking skin and thereby, PhytoCodine® directly contributes to a person’s perceived age.
Magnificent Combination
Active Component: Matrikine-Like Peptides
PhytoCodine® contains natural matrikine-like peptides from cedar nuts that enhance extracellular matrix (ECM formation). Matrikines naturally occur in our skin and activate intracellular signaling pathways that lead to a build-up of the extracellular matrix.
Functional Component: For Bioactive Peptides
PhytoCodine® enhances the penetration of matrikine-like peptides. Peptides are small molecules that must penetrate skin layers to reach dermal fibroblasts (their point of action). PhytoCodine® comes with a liposomal carrier system for hydrophilic active ingredients that enhances penetration. In fact, in vivo studies using Raman spectroscopy demonstrate that penetration of model actives increased by 50% after topical application.
Functional Component: Natural Eleutherosides
PhytoCodine® protects the bioactivity of matrikine-like peptides. Matrikine-like messenger peptides are sensitive to proteolytic degradation. Protease activity in the extracellular space quickly cleaves peptides, extinguishing their biological activity. Likewise, collagen and elastin are sensitive to proteolytic degradation. PhytoCodine® contains natural eleuthe rosides – highly potent protease inhibitors from Siberian ginseng (Eleutherococcus senticosus).
Figure 4: PhytoCodine® is composed of natural messenger peptides mimicking the action of matrikines that naturally occur in our skin. Thereby, PhytoCodine® activates the formation of extracellular matrix proteins and improves age-related properties of mature skin.
Beren Elmasdiken
Chemical Engineer
Chief Sales & Marketing Officer
Oktrade Dış Tic. Ltd. Şti.
