J-DERMIST
Aging Factors
There are many factors that affect the aging of the skin. Aging factors are numerous : biological factors, lifestyle factors, environmental factors. The genetic factors that comes from our inherit from previous generations and the gravity that permanently affect the resistance of our tissues cannot be controlled in daily life.
The Effect of Gravity with Aging
When the production of collagen and elastin is diminished, the skin, less firm and subject to the effects of gravity, stretches without being able to retract. As a result of the loss of elasticity, the skin texture loosens, its fullness decreases and the expression lines become more pronounced.
As a result, the face loses its oval shape and takes the form of an inverted V. To restore the old form to the skin; Inspired by the erect stems of the Isodon japonicus plant, known as “Enmei-so”, meaning “herb that prolongs life” in Japanese, it is aimed to eliminate the negative effects of gravity on the maturing skin.
Isodon Japonicus – Flexibility & Rigidity
Its stems can reach up to 2m high. This ability to stand upright despite the effect of gravity is due to the composition of its support tissue, which provides both flexibility and rigidity.
Lignin, Key Component of Supporting Tissues
The sclerenchyma, thanks to lignin (in green on the picture), is a tissue of rigid cells bringing its mechanical resistance to the plant. Counteracting the effects of gravity on the supporting tissues involves the improvement of the sinusoidal architecture of the dermal-
epidermal junction (DEJ) as well as the density of the dermis.
DEJ components are derived from the activity of keratinocytes and fibroblasts. Ageing
is occurred when loss of physical undulation and the support.It is aimed to restore
the skin to its original state by increasing the activity of keratinocytes and fibroblasts.
With the slowing of metabolic activity of fibroblasts in the dermis region, flexibility decreases and the skin ages. As a result of reactivating the synthesis of extracellular
matrix components and structural factors, the skin is renewed and rejuvenated.
Action Mechanism of J-DERMIST
J-DERMIST focus on reactivation of the metabolic activity of keratinocytes and reactivation of the metabolic activity of fibroblasts. And also J-DERMIST reorganized the tissue of the Extra-Cellular Matrix.
Reactivation of the metabolic activity of keratinocytes
The components of the DEJ are synthesized by both keratinocytes and fibroblasts. Rejuvenation of the DEJ therefore depends in part on reactivating the metabolic synthesis of keratinocytes. J-DERMIST stimulates the metabolic synthesis of keratinocytes by +44%.
This action will be favorable to the cohesion of the epidermis as well as to the reconstruction of the DEJ.
In order to prove the regeneration of metabolic activity of fibroblasts, In-Vitro tests were performed with 0.2 percent J-DERMIST for 24 hours. Gene expression analysis is performed using the PCR-Array designed for the dermal matrix.
The results were schematized as follows: expression of genes involved in collagen synthesis and maturation (a), expression of genes involved in proteoglycan and glycoprotein synthesis (b), and expression of genes involved in DEJ binding and composition (c).
New Method in the Analysis of External Cell Matrix Fibers
For fiber analysis of the Extracellular Matrix, both the density and quality of collagen fibers are measured using the Kamax method. XPolar® technology is used to characterize and measure in the Kamax method. Codif laboratories were one of the first laboratories to use this method for antiaging
application.
What Is the Thechnologie Xpolar?*
A polarisation imaging solution to translate and quantify biological changes through images. Collagen fibres can be observed qualitatively between crossed polarizers (Fig. B) this does not allow the quantification of possible changes in the state of collagen.
The XPolar® technology allows to quantify the polarisation change, through a dimensional number, called Kmax (Fig. C) A modification/ageing of the collagen will result in a decrease in the Kmax measured. For example, the Kmax parameter can be used to monitor collagen degradation or to quantify the effectiveness of an active ingredient.
J-Dermist Increases the Quality of Support Fibers up to 60%
The protocol of this test analyzed with KAMAX technology; Topical application of 1% J-DERMIST is performed on human skin explants taken from a 49-year-old donor, 1 day apart, for 7 days. At the end of the 7th day, a qualitative analysis of the collagen fibers in the skin tissue is performed and it is concluded that the quality of the fiber structures has increased up to 60%.
In another In-Vivo test, 28-day use of 2% J-DERMIST is the opinion that the effect of gravity on wrinkles is reduced. This test was conducted among 30 volunteers aged 41 to 68 years, and the results were schematized with 3D analyzers.
An assessment of resistance to gravity was made by analysis of the nasolabial fold (wrinkles around the nose) in the sitting position (maximum gravity exposure) and supine position (minimum gravity exposure).
We also analyzed the effect of gravity on tissue relaxation, along with the difference in volume of the nasolabial fold (wrinkles around the nose) between sitting and lying positions.
While the depth of wrinkles is at maximum level at T0 and in the sitting position, this rate shows a 7 percent decrease compared to the baseline and placebo after 28 days of use of J-DERMIST.
The above figure shows the test results when exposed to gravity on the 28th day and the initial time where the points where the effect of gravity is the least. As a result of this test using a 2 percent J-DERMIST product, it was determined that the wrinkle depth at T28
(sitting position/gravity effect is felt maximum) is significantly less than the depth at T0 moment (recumbent position/gravity effect is felt at minimum).
Berk Hakkı Gazioğlu – Sales Executive – Cosmetic Department
Arerko Kimya Sanayi ve Ticaret A.Ş.
